Benchmark Almanac

LAB-Bench FigQA

Claude Opus 4.8 80.4% leads since May 2026 Only in system cards

Models interpret figures from biology papers and answer multiple-choice questions. FigQA subset of LAB-Bench.

Anthropic reports LAB-Bench subsets separately in its RSP bio sections.

In the authors’ words

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and reasoning on textbook-style science questions, but few if any benchmarks are designed to evaluate language model performance on practical tasks required for scientific research, such as literature search, protocol planning, and data analysis. As a step toward building such benchmarks, we introduce the Language Agent Biology Benchmark (LAB-Bench), a broad dataset of over 2,400 multiple choice questions for evaluating AI systems on a range of practical biology research capabilities, including recall and reasoning over literature, interpretation of figures, access and navigation of databases, and comprehension and manipulation of DNA and protein sequences. Importantly, in contrast to previous scientific benchmarks, we expect that an AI system that can achieve consistently high scores on the more difficult LAB-Bench tasks would serve as a useful assistant for researchers in areas such as literature search and molecular cloning. As an initial assessment of the emergent scientific task capabilities of frontier language models, we measure performance of several against our benchmark and report results compared to human expert biology researchers. We will continue to update and expand LAB-Bench over time, and expect it to serve as a useful tool in the development of automated research systems going forward. A public subset of LAB-Bench is available for use at the following URL: https://huggingface.co/datasets/futurehouse/lab-bench

Abstract of LAB-Bench: Measuring Capabilities of Language Models for Biology Research (arXiv:2407.10362, CC0)
Made by FutureHouse Released Jul 2024 Genomics and life sciences All tasks public Last in a system card Jun 2026 Last model added Jun 2026
Level
Expert Specialists with years of training, often over hours of work
Scored
Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
Answers
Multiple choice
10
Models scored in lab cards
14
System cards report it, from 2 labs

Claude Opus 4.8 leads with 80.4% among models released by May 2026

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

The newest model with a score here came out in May 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:

  1. 1 Claude Opus 4.8 80.4%
  2. 2 Claude Mythos Preview 79.7%
  3. 3 Claude Opus 4.7 78.6%
  4. 4 Claude Sonnet 4.6 58.8%
  5. 5 Claude Opus 4.6 58%
  6. 6 Claude Opus 4.5 54.9%
  7. 7 Claude Sonnet 4.5 49.7%
  8. 8 Claude Haiku 4.5 49%
  9. 9 Claude Opus 4.1 46%
  10. 10 Grok 4.1 34%
#ModelScoreSettingDateSource
1 Claude Opus 4.8 80.4% May 2026 Model card
2 Claude Mythos Preview 79.7% Apr 2026 Model card
3 Claude Opus 4.7 78.6% Apr 2026 Model card
4 Claude Sonnet 4.6 58.8% Feb 2026 Model card
5 Claude Opus 4.6 58% Feb 2026 Model card
6 Claude Opus 4.5 54.9% Nov 2025 Model card
7 Claude Sonnet 4.5 49.7% Sep 2025 Model card
8 Claude Haiku 4.5 49% Oct 2025 Model card
9 Claude Opus 4.1 46% Aug 2025 Model card
10 Grok 4.1 34% Nov 2025 Model card

7 models have held number one since its release in Jul 2024

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic
Lab claims Replaced by LABBench2 FigQA2, May 2026

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Claude Opus 4.8 Claude Sonnet 4.6 Claude Opus 4.5 Claude Sonnet 4.5 0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Claude Opus 4.8 Claude Sonnet 4.6

Labs report it only in system cards

We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.

14 system cards report it, from 2 labs

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
9 Jun 2026 Claude Fable 5 system card LAB-Bench FigQA, the card says Fable 5 showed a degradation because its bio-safeguard classifiers flag biology figures, no Fable 5 number printed (8.16.7) Capabilities
28 May 2026 Claude Opus 4.8 system card 80.4 LAB-Bench FigQA, 181 public questions, no tools, max effort, five runs, new grader (87.3% with Python tools) (8.12.3) Capabilities
16 Apr 2026 Claude Opus 4.7 system card 78.6 LAB-Bench FigQA, adaptive thinking at max effort, no tools. 86.4 with Python tools (8.9.1) Capabilities
7 Apr 2026 Claude Mythos Preview system card 79.7 LAB-Bench FigQA, adaptive thinking, max effort, no tools, average of five runs (6.11.1); 89.0 with Python tools Capabilities
17 Feb 2026 Claude Sonnet 4.6 system card 58.8 LAB-Bench FigQA, adaptive thinking, max effort, no tools; 77.1 with an image cropping tool (2.17.1) Capabilities
5 Feb 2026 Claude Opus 4.6 system card 58 LAB-Bench FigQA, adaptive thinking, max effort, no tools, average of five runs (2.19.1); 78.3 with an image cropping tool Capabilities
24 Nov 2025 Claude Opus 4.5 system card 54.9 LAB-Bench FigQA, no tools, extended thinking off, 0-shot (2.21; 69.2% with image cropping tool and 32,768 reasoning tokens, 0.6924 in 7.2.4.4) Capabilities
17 Nov 2025 Grok 4.1 model card 34 FigQA, accuracy 0.34, Grok 4.1 Thinking (Table 4) Bio and chem risk
15 Oct 2025 Claude Haiku 4.5 system card 49 LAB-Bench FigQA, k-shots=10, score 0.49 (6.2.3.1) Bio and chem risk
29 Sep 2025 Claude Sonnet 4.5 system card 49.7 LAB-Bench FigQA (Figure QA), 10-shot, no tools, score 0.497 (Figure 9.2.4.4.A) Bio and chem risk
5 Aug 2025 Claude Opus 4.1 system card addendum 46 LAB-Bench subset FigQA 0.46 (6.3.1.2) Bio and chem risk
22 May 2025 Claude Sonnet 4 system card LAB-Bench FigQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) Bio and chem risk
22 May 2025 Claude Opus 4 system card LAB-Bench FigQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) Bio and chem risk
24 Feb 2025 Claude 3.7 Sonnet system card LabBench subset FigQA, 0 and 5 shots with Bo1 to Bo10, 32k thinking, chart without printed values (Figures 18 and 19) Bio and chem risk

Versions

More in Biology and chemistry

All 96 in Biology and chemistry
  • SUPERChem In use Models solve 500 expert-written chemistry reasoning problems, offered in multimodal and text-only forms. Expert solution paths also allow a reasoning path score. Tencent Hy4 preview 66.4%
  • GeneBench Pro In use Agents analyze messy simulated genomics and biology datasets to estimate a decision-relevant quantity across 129 problems. Scored automatically against known answers. GPT-6 Astra 37.1%
  • LifeSciBench In use Models complete 750 expert-written life science research tasks, often with attached figures, tables, or sequence files. Graded against expert rubrics as score and pass rate. GPT-6 Astra 60.3%
  • MolecularIQ In use Models answer questions about molecular graphs, such as counting, indexing and constrained generation, and a symbolic checker verifies each answer. Intern-S2-397B 62.4%
  • TOMG-Bench In use Models generate molecules from natural language requests in three tasks: molecule editing, molecule optimization and customized generation. Each output is checked for validity and for meeting the requested properties. Intern-S2-397B 66.8%
  • BABE Fading Models reason from experimental results in peer-reviewed biology papers to draw conclusions, with causal and cross-scale inference. Seed2.0 Lite (0428) 57.9%