Benchmark Almanac

GeneBench Pro

GPT-6 Astra 37.1% leads since Sep 2026 In use

Agents analyze messy simulated genomics and biology datasets to estimate a decision-relevant quantity across 129 problems. Scored automatically against known answers.

129 problems in 10 domains and 21 sub-domains. Synthetic noisy datasets graded against ground truth. OpenAI calls it a harder expansion of GeneBench. Self-reported scores only so far.

Made by OpenAI Released Jun 2026 Genomics and life sciences Public tasks plus a private test set Last in a launch post Sep 2026 Last model added Sep 2026
Level
Expert Specialists with years of training, often over hours of work
Scored
Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
Answers
Agent task Many steps in a terminal, browser, desktop, app, game or robot.
4
Models scored in lab cards
4
Launch posts list it, from 1 lab

GPT-6 Astra leads with 37.1% among models released by Sep 2026

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

The newest model with a score here came out in Sep 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:

  1. 1 GPT-6 Astra 37.1%
  2. 2 GPT-5.6 Sol 28.7%
  3. 3 GPT-5.6 Terra 23.3%
  4. 4 GPT-5.6 Luna 10.8%
#ModelScoreSettingDateSource
1 GPT-6 Astra 37.1% Sep 2026 Model card
2 GPT-5.6 Sol 28.7% Jul 2026 Model card
3 GPT-5.6 Terra 23.3% Jul 2026 Model card
4 GPT-5.6 Luna 10.8% Jul 2026 Model card

2 models have held number one since its release in Jun 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

OpenAI
Lab claims Not tested since Sep 2026
GPT-6 Astra 37.1%

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% Near the ceiling (85%) GPT-6 Astra GPT-5.6 Sol 0% 20% 40% 60% 80% 100% Near the ceiling (85%) GPT-6 Astra GPT-5.6 Sol

One lab put it in a launch post in the last six months

Launch posts from every lab that has listed it, one tick per post. Tall colored ticks include it, and short gray ones leave it out.

OpenAI
DateLaunch postScoreAs the post writes it
3 Sep 2026 GPT-6 Astra 37.1 GeneBench Pro
9 Jul 2026 GPT-5.6 Luna 10.8 GeneBench Pro
9 Jul 2026 GPT-5.6 Terra 23.3 GeneBench Pro
9 Jul 2026 GPT-5.6 Sol 28.7 GeneBench Pro (Sol, max)

More in Biology and chemistry

All 96 in Biology and chemistry
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  • LifeSciBench In use Models complete 750 expert-written life science research tasks, often with attached figures, tables, or sequence files. Graded against expert rubrics as score and pass rate. GPT-6 Astra 60.3%
  • MolecularIQ In use Models answer questions about molecular graphs, such as counting, indexing and constrained generation, and a symbolic checker verifies each answer. Intern-S2-397B 62.4%
  • TOMG-Bench In use Models generate molecules from natural language requests in three tasks: molecule editing, molecule optimization and customized generation. Each output is checked for validity and for meeting the requested properties. Intern-S2-397B 66.8%
  • BABE Fading Models reason from experimental results in peer-reviewed biology papers to draw conclusions, with causal and cross-scale inference. Seed2.0 Lite (0428) 57.9%
  • Biology-Instructions Fading Models answer multi-omics sequence tasks on DNA, RNA, protein and multi-molecule inputs, such as property prediction and interaction tasks. Scored per task with task metrics. Intern-S2-397B 55.7%