Benchmark Almanac

VIALS

Not in model cards

Vision models answer 161 questions about lab images such as gel blots, plasmid maps, microscopy and flow cytometry plots. An LLM judge grades each answer against a key.

Images come from everyday biotech work, not published figures. Judge is GPT-5 mini. Version 2.0.0 on 2026-10-30 revised 3 of 161 tasks after expert review, so scores stay close to version 1.0.0.

In the authors’ words

In professional life sciences workflows, scientists routinely interpret visual artifacts (gel blots, microscopy images, plasmid maps, flow cytometry plots, molecular structures, ...) to inform research decisions. We introduce VIALS, a visual question-answering benchmark with 161 such interpretation tasks, spanning the types of artifacts examined throughout experimental workflows in the biotech industry (rather than polished figures from publications and textbooks). While frontier vision-language models can now fluently describe natural images, we find that they are unable to accurately interpret these scientific images, reflecting limitations in domain knowledge and domain-specific visual reasoning capabilities. In contrast, scientists with relevant domain expertise find these visual interpretation tasks straightforward. AI that cannot similarly interpret such images will have limited utility in professional life sciences workflows, where such artifacts are central to how scientists reason, communicate, and make decisions.

Abstract of VIALS: A Benchmark for Visual Interpretation of Artifacts in the Life Sciences (arXiv:2608.21357, CC0)
Made by Handshake AI Research Released Aug 2026 Genomics and life sciences All tasks public
Level
Expert Specialists with years of training, often over hours of work
Scored
Graded by a model A language model scores each response, usually against a rubric.
Answers
Short answer A number, word or short string matched to a key.

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