SHP2 Protein Function Prediction
Models predict held-out assay measurements for single amino acid variants of SHP2. Scored as mean R squared over three assay datasets.
OpenAI Critical bio capability evaluation. The Critical threshold is 0.60.
- Level
- Research frontier Researchers, on open problems or tasks that take days
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Prediction Probabilities for events that have not happened yet.
GPT-6 Astra leads with 0.40
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 GPT-6 Astra 0.40
- 2 GPT-6.1 Terra 0.37
- 3 GPT-6.1 Sol 0.33
- 4 GPT-6 Sol 0.27
- 5 GPT-6 Luna 0.21
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-6 Astra | 0.40 | Sep 2026 | Model card | |
| 2 | GPT-6.1 Terra | 0.37 | Oct 2026 | Model card | |
| 3 | GPT-6.1 Sol | 0.33 | Sep 2026 | Model card | |
| 4 | GPT-6 Sol | 0.27 | Sep 2026 | Model card | |
| 5 | GPT-6 Luna | 0.21 | Oct 2026 | Model card |
Number one over time
Lab claims count from the day the card came out, independent runs from the model’s release.
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
7 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 29 Oct 2026 | GPT-6 Luna system card addendum | 0.21 | SHP2 Protein Function Prediction, mean R² (Table 9) | Bio and chem risk |
| 26 Oct 2026 | GPT-6.1 Terra system card addendum | 0.37 | SHP2 Protein Function Prediction, mean R² across three assay datasets (table, 9.0.1.2) | Bio and chem risk |
| 7 Oct 2026 | GPT-6 Sol system card addendum | 0.23 | SHP2 Protein Function Prediction, mean R² (Table 9) | Bio and chem risk |
| 7 Oct 2026 | GPT-6 Luna system card addendum | 0.13 | SHP2 Protein Function Prediction, mean R² (Table 9) | Bio and chem risk |
| 29 Sep 2026 | GPT-6.1 Sol system card addendum | 0.332 | SHP2 Protein Function Prediction, mean R² (9.1.1.2) | Bio and chem risk |
| 22 Sep 2026 | GPT-6 Sol system card | 0.273 | SHP2 Protein Function Prediction, mean R² (Table 34, A.8.1.1.2) | Bio and chem risk |
| 3 Sep 2026 | GPT-6 Astra system card | 0.4 | SHP2 Protein Function Prediction, mean R² (helpful-only 0.35) (Table 13) | Bio and chem risk |
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