Short-horizon computational biology tasks
Only in system cards
Agents perform end-to-end computational tasks related to modifying and engineering biological agents.
In-house Anthropic evaluation. The tasks are not public.
Made by Anthropic Released May 2025 Hazardous knowledge Tasks kept private Last in a system card Feb 2026
Last model added Feb 2026
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Agent task Many steps in a terminal, browser, desktop, app, game or robot.
7
System cards report it, from 1 lab
No scores here yet
No lab, leaderboard or Epoch AI run has reported a score for Short-horizon computational biology tasks yet.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
7 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 17 Feb 2026 | Claude Sonnet 4.6 system card | Short-horizon computational biology tasks, crossed lower-bound rule-out thresholds on 3/6 tasks, chart without printed values (Figure 6.2.2.5.A) | Bio and chem risk | |
| 5 Feb 2026 | Claude Opus 4.6 system card | Short-horizon computational biology tasks, 6 tasks with no overall, crossed lower-bound rule-out thresholds on 6/6 tasks, chart without printed values (8.2.4.9, Figure 8.2.4.9.A) | Bio and chem risk | |
| 24 Nov 2025 | Claude Opus 4.5 system card | Short-horizon computational biology tasks, 6 tasks with no overall, crossed lower-bound rule-out thresholds on 3/6 tasks, chart without printed values (7.2.4.6, Figure 7.2.4.6.A) | Bio and chem risk | |
| 29 Sep 2025 | Claude Sonnet 4.5 system card | Short-horizon computational biology tasks, 6 tasks with no overall, helpful-only variant, box plot without printed values. Below the rule-out bar on 3 of 6 tasks (9.2.4.6, Figure 9.2.4.6.A) | Bio and chem risk | |
| 5 Aug 2025 | Claude Opus 4.1 system card addendum | Short-horizon computational biology tasks, six tasks, box plot without printed values. 4 of 6 below the rule-out bar (Figure 6.3.1.1.A) | Bio and chem risk | |
| 22 May 2025 | Claude Sonnet 4 system card | Short-horizon computational biology tasks, six tasks, box plot without printed values. 4 of 6 below the rule-out bar (Figure 7.2.4.9.A) | Bio and chem risk | |
| 22 May 2025 | Claude Opus 4 system card | Short-horizon computational biology tasks, six tasks, box plot without printed values. 4 of 6 below the rule-out bar (Figure 7.2.4.9.A) | Bio and chem risk |
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