Mol-Instructions
Intern-S2-397B 54% leads since Sep 2026 Fading Models answer molecule-oriented, protein-oriented and biomolecular text instructions, such as reaction prediction, molecule description and protein function questions. Scored per task with task metrics.
It is mainly an instruction-tuning dataset. Labs report its test split as a benchmark.
In the authors’ words
Large Language Models (LLMs), with their remarkable task-handling capabilities and innovative outputs, have catalyzed significant advancements across a spectrum of fields. However, their proficiency within specialized domains such as biomolecular studies remains limited. To address this challenge, we introduce Mol-Instructions, a comprehensive instruction dataset designed for the biomolecular domain. Mol-Instructions encompasses three key components: molecule-oriented instructions, protein-oriented instructions, and biomolecular text instructions. Each component aims to improve the understanding and prediction capabilities of LLMs concerning biomolecular features and behaviors. Through extensive instruction tuning experiments on LLMs, we demonstrate the effectiveness of Mol-Instructions in enhancing large models' performance in the intricate realm of biomolecular studies, thus fostering progress in the biomolecular research community. Mol-Instructions is publicly available for ongoing research and will undergo regular updates to enhance its applicability.
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Short answer A number, word or short string matched to a key.
Intern-S2-397B leads with 54%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 Intern-S2-397B 54%
- 2 Intern-S1-Pro 48.8%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Intern-S2-397B | 54% | Sep 2026 | Model card | |
| 2 | Intern-S1-Pro | 48.8% | Feb 2026 | Model card |
2 models have held number one since its release in Jun 2023
Lab claims count from the day the card came out, independent runs from the model’s release.
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs headline it less often now, last in Sep 2026
Launch posts from every lab that has listed it, one tick per post. Tall colored ticks include it, and short gray ones leave it out.
| Date | Launch post | Score | As the post writes it |
|---|---|---|---|
| 13 Sep 2026 | Intern-S2-397B | 54 | Mol-Instructions (Bio-molecular Instruction) |
| 2 Feb 2026 | Intern-S1-Pro | 48.8 | Mol-Instructions |
One system card reports it
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 26 Mar 2026 | Intern-S1-Pro technical report | 48.8 | Mol-Instructions, Bio-molecular Instruction, non-thinking (Table 2) | Capabilities |
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