Long-form virology tasks
Claude 3.7 Sonnet 69.7% Only in system cards
Agents complete end-to-end pathogen acquisition workflows, covering workflow design and laboratory protocols. Scored against expert criteria.
Anthropic evaluation built with SecureBio, Deloitte and Signature Science. The tasks are not public. Retired in the Claude Opus 5.5 system card, which calls them largely saturated and prone to refusals, and replaced by the Protocols and BioMysteryBench evaluations.
Made by Anthropic Released Feb 2025 Hazardous knowledge Tasks kept private Last in a system card Jul 2026
Last model added Jul 2026
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Graded by people Human experts grade or compare the outputs.
- Answers
- Agent task Many steps in a terminal, browser, desktop, app, game or robot.
1
Model scored in lab cards
14
System cards report it, from 1 lab
Claude 3.7 Sonnet leads with 69.7%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude 3.7 Sonnet | 69.7% | Feb 2025 | Model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Reported by the lab in its model card
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
14 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 24 Jul 2026 | Claude Opus 5 system card | Long-form virology tasks, two tasks with no overall: Task 1 end-to-end 0.802 and Task 2 end-to-end 0.872 (0.87 on chart), highest-scoring snapshot (2.2.4, Figure 2.2.4.A) | Bio and chem risk | |
| 30 Jun 2026 | Claude Sonnet 5 system card | Long-form virology tasks, end-to-end score Task 1 0.79 and Task 2 0.90, no overall, highest score across snapshots (2.2.4, Figure 2.2.4.A) | Bio and chem risk | |
| 28 May 2026 | Claude Opus 4.8 system card | Long-form virology tasks, two tasks with no overall: task 1 end-to-end 0.77 (sequence design 0.88, protocol design 0.87), task 2 end-to-end 0.90 (sequence design 1.00, protocol design 0.90, corrected from 0.89 in the June 17, 2026 changelog) (Table 2.2.3.B, 2.2.4) | Bio and chem risk | |
| 16 Apr 2026 | Claude Opus 4.7 system card | Long-form virology tasks, end-to-end score, task 1 0.82 and task 2 0.94, no overall, highest score across snapshots (2.2.5.2, Figure 2.2.5.2.A) | Bio and chem risk | |
| 7 Apr 2026 | Claude Mythos Preview system card | Long-form virology tasks, end-to-end score, task 1 0.81 and task 2 0.94, no overall (2.2.5.4, Figure 2.2.5.4.A) | Bio and chem risk | |
| 17 Feb 2026 | Claude Sonnet 4.6 system card | Long-form virology tasks, max of 5 score, task 1 0.84 and task 2 0.89, no overall (6.2.2.1) | Bio and chem risk | |
| 5 Feb 2026 | Claude Opus 4.6 system card | Long-form virology tasks, max of 5 score, task 1 (influenza) 0.79 and task 2 (SARS-CoV) 0.9, no overall (8.2.4.1) | Bio and chem risk | |
| 24 Nov 2025 | Claude Opus 4.5 system card | Long-form virology tasks, two tasks with no overall: task 1 max of 5 score 0.845, task 2 pass@5 score 0.912 (7.2.4.1) | Bio and chem risk | |
| 15 Oct 2025 | Claude Haiku 4.5 system card | Long-Form Virology Task 1 0.76 (Sequence 0.87, Protocol 0.88) and Task 2 0.17 (Sequence 0.19, Protocol 0.87), no overall (6.2.3.1) | Bio and chem risk | |
| 29 Sep 2025 | Claude Sonnet 4.5 system card | Long-form virology tasks, two tasks with no overall: Task 1 max of 5 end-to-end score 0.89 (sequence design 0.98, protocol design 0.90), Task 2 pass@5 end-to-end score 0.88 (sequence 0.97, protocol 0.91) (9.2.4.1, Figures 9.2.4.1.A and 9.2.4.1.B) | Bio and chem risk | |
| 5 Aug 2025 | Claude Opus 4.1 system card addendum | Long-form virology tasks, two tasks with no overall: Task 1 score 0.86 (sequence design 0.98, protocol design 0.87), Task 2 score 0.67 (sequence design 0.85, protocol design 0.79) (6.3.1.2) | Bio and chem risk | |
| 22 May 2025 | Claude Sonnet 4 system card | Long-form virology tasks, two tasks with no overall: Task 1 end-to-end max of 5 score 0.55, Task 2 end-to-end pass@5 score 0.635 (7.2.4.3, Figures 7.2.4.3.A and B) | Bio and chem risk | |
| 22 May 2025 | Claude Opus 4 system card | Long-form virology tasks, two tasks with no overall: Task 1 end-to-end max of 5 score 0.83, Task 2 end-to-end pass@5 score 0.720 (7.2.4.3, Figures 7.2.4.3.A and B) | Bio and chem risk | |
| 24 Feb 2025 | Claude 3.7 Sonnet system card | 69.7 | Long-form virology tasks, score 69.7% under the most conservative scoring (7.1.4) | Bio and chem risk |
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