DNA sequence design for transcription factor binding
Models design DNA sequences that bind 11 Nucleobench transcription factors, scored by BPNet oracles against the Ledidi baseline. Scored as pass@1.
OpenAI Preparedness evaluation. The concern threshold is an 80 percent win rate over Ledidi.
- Level
- Research frontier Researchers, on open problems or tasks that take days
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Prediction Probabilities for events that have not happened yet.
GPT-5.5 Pro leads with 16.5% among models released by Sep 2026
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in Sep 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- Claude Opus 5.5
- GPT-6.1 Terra
- GPT-6.1 Sol
- Claude Sonnet 5.5
- and 12 more
- 1 GPT-5.5 Pro 16.5%
- 2 GPT-5.5 13.8%
- 3 GPT-5.6 Sol 13.7%
- 4 GPT-6 Astra 11.3%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-5.5 Pro | 16.5% | Apr 2026 | Model card | |
| 2 | GPT-5.5 | 13.8% | Apr 2026 | Model card | |
| 3 | GPT-5.6 Sol | 13.7% | Jun 2026 | Model card | |
| 4 | GPT-6 Astra | 11.3% | Sep 2026 | Model card |
Number one over time
Lab claims count from the day the card came out, independent runs from the model’s release.
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
6 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 3 Sep 2026 | GPT-6 Astra system card | 11.3 | DNA sequence design for Transcription Factor binding, pass@1 win rate over Ledidi, retiring evaluation (Table 17) | Bio and chem risk |
| 6 Aug 2026 | GPT-5.6 Sol system card addendum | 12.6 | DNA sequence design for Transcription Factor binding, pass@1, GPT-5.6 Sol (August) (7.1.1.6) | Bio and chem risk |
| 9 Jul 2026 | GPT-5.6 Sol system card | 13.7 | DNA sequence design for transcription factor binding, pass@1 (Table 3, 9.1.1.7) | Bio and chem risk |
| 25 Jun 2026 | GPT-5.6 Sol system card | 13.7 | DNA sequence design for transcription factor binding, pass@1 (Table 3, 9.1.1.7) | Bio and chem risk |
| 23 Apr 2026 | GPT-5.5 system card | 13.8 | DNA sequence design for Transcription Factor binding, pass@1 (Table 13) | Bio and chem risk |
| 23 Apr 2026 | GPT-5.5 Pro system card | 16.5 | DNA sequence design for Transcription Factor binding, pass@1, GPT-5.5 Pro (Table 13) | Bio and chem risk |
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