Benchmark Almanac

Coronavirus-ACE2 Cell-Entry Screen

GPT-6.1 Terra 0.47 leads since Oct 2026 Only in system cards

Models predict and rank held-out cell entry measurements for spike protein and ACE2 pairings. Scored as a composite score.

OpenAI Critical bio capability evaluation. The Critical threshold is 0.75.

Made by OpenAI Released Sep 2026 Genomics and life sciences Tasks kept private Last in a system card Oct 2026 Last model added Oct 2026
Level
Research frontier Researchers, on open problems or tasks that take days
Scored
Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
Answers
Prediction Probabilities for events that have not happened yet.
5
Models scored in lab cards
7
System cards report it, from 1 lab

GPT-6.1 Terra leads with 0.47

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

  1. 0.47 GPT-6.1 Terra
  2. 0.46 GPT-6 Sol
  3. 0.42 GPT-6.1 Sol
  4. 0.42 GPT-6 Astra
  5. 0.37 GPT-6 Luna
  1. 1 GPT-6.1 Terra 0.47
  2. 2 GPT-6 Sol 0.46
  3. 3 GPT-6.1 Sol 0.42
  4. 4 GPT-6 Astra 0.42
  5. 5 GPT-6 Luna 0.37
#ModelScoreSettingDateSource
1 GPT-6.1 Terra 0.47 Oct 2026 Model card
2 GPT-6 Sol 0.46 Sep 2026 Model card
3 GPT-6.1 Sol 0.42 Sep 2026 Model card
4 GPT-6 Astra 0.42 Sep 2026 Model card
5 GPT-6 Luna 0.37 Oct 2026 Model card

3 models have held number one since its release in Sep 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

OpenAI
Lab claims 3 leaders
GPT-6.1 Terra 0.47

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card
0.30 0.35 0.40 0.45 0.50 2027 0.30 0.35 0.40 0.45 0.50 2027

Labs report it only in system cards

We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.

7 system cards report it, from 1 lab

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
29 Oct 2026 GPT-6 Luna system card addendum 0.37 Coronavirus–ACE2 Cell-Entry Screen, composite score (Table 9) Bio and chem risk
26 Oct 2026 GPT-6.1 Terra system card addendum 0.474 Coronavirus–ACE2 Cell-Entry Screen, clipped composite score (table, 9.0.1.2) Bio and chem risk
7 Oct 2026 GPT-6 Sol system card addendum 0.349 Coronavirus–ACE2 Cell-Entry Screen, composite score (Table 9) Bio and chem risk
7 Oct 2026 GPT-6 Luna system card addendum 0.36 Coronavirus–ACE2 Cell-Entry Screen, composite score (Table 9) Bio and chem risk
29 Sep 2026 GPT-6.1 Sol system card addendum 0.423 Coronavirus–ACE2 Cell-Entry Screen, composite score (9.1.1.2) Bio and chem risk
22 Sep 2026 GPT-6 Sol system card 0.463 Coronavirus–ACE2 Cell-Entry Screen, composite score (Table 34, A.8.1.1.2) Bio and chem risk
3 Sep 2026 GPT-6 Astra system card 0.42 Coronavirus–ACE2 Cell-Entry Screen, composite score (table shows helpful-only 0.45) (10.1.1.2.3, Table 14) Bio and chem risk

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