Black-box RNA sequence modeling and design
Only in system cards
Models predict scores for unlabeled RNA sequences from labeled data, then design new sequences. Results are compared with 57 human experts.
Built with Dyno Therapeutics for the CB-2 threshold. Reported as design and rank-correlation prediction scores in charts.
Made by Anthropic (with Dyno Therapeutics) Released May 2026 Hazardous knowledge Tasks kept private Last in a system card Oct 2026
Last model added Oct 2026
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Agent task Many steps in a terminal, browser, desktop, app, game or robot.
8
System cards report it, from 1 lab
No scores here yet
No lab, leaderboard or Epoch AI run has reported a score for Black-box RNA sequence modeling and design yet.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
8 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 7 Oct 2026 | Claude Haiku 5.5 system card | Black-box RNA sequence modeling and design (Dyno), design and prediction scores, chart without printed values (Figures 2.2.3.1.A and 2.2.3.1.B) | Bio and chem risk | |
| 28 Sep 2026 | Claude Sonnet 5.5 system card | Black-box RNA sequence modeling and design, design and prediction scores, chart without printed values (2.2.3.1, Figures 2.2.3.1.A and B) | Bio and chem risk | |
| 22 Sep 2026 | Claude Opus 5.5 system card | Black-box RNA sequence modeling and design (Dyno), design and prediction scores, chart without printed values. Text says the top design score exceeds the 75th human percentile (2.2.3.2.1, Figures 2.2.3.2.1.A and B) | Bio and chem risk | |
| 24 Jul 2026 | Claude Opus 5 system card | Black-box RNA sequence modeling and design (Dyno), top and median design scores and prediction scores, baseline and in-context iteration, chart without printed values. Text says it exceeds the 75th human percentile on design and prediction (2.2.5.1, Figures 2.2.5.1.A and B) | Bio and chem risk | |
| 30 Jun 2026 | Claude Sonnet 5 system card | Black-box RNA sequence modeling and design (Dyno), design and prediction scores over eight attempts, chart without printed values. Text: prediction score above the 90th human percentile (2.2.5.1, Figures 2.2.5.1.A and B) | Bio and chem risk | |
| 28 May 2026 | Claude Opus 4.8 system card | Black-box RNA sequence modeling and design (Dyno), eight attempts, no overall: design score top 10.06 and median 6.84, prediction score (Spearman) all sequences 0.786 and top 5% -0.029, no prior context (Table 2.2.3.B, 2.2.5.1) | Bio and chem risk | |
| 16 Apr 2026 | Claude Opus 4.7 system card | Sequence-to-function modeling and design (Dyno), prediction and design scores, chart without printed values. Text says prediction exceeds the 90th human percentile and design stays below the 75th (2.2.5.3, Figure 2.2.5.3.A) | Bio and chem risk | |
| 7 Apr 2026 | Claude Mythos Preview system card | Sequence-to-function modeling and design (Dyno Therapeutics), prediction and design scores over 8 attempts, chart without printed values. Text says the mean beats the 75th human percentile on both and the 90th on prediction, below the top human (2.2.5.5, Figure 2.2.5.5.A) | Bio and chem risk |
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