Bioweapons knowledge questions
Models answer 33 sensitive bioweapons questions written by Deloitte biosecurity staff. Answers are compared with novice, intermediate and expert baselines.
In-house Anthropic evaluation. The tasks are not public.
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Graded by people Human experts grade or compare the outputs.
- Answers
- Short answer A number, word or short string matched to a key.
3 models share the top score of 51.5% among models released by May 2025
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in May 2025, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- GPT-6 Astra
- Claude Opus 5.5
- GPT-6.1 Terra
- GPT-6.1 Sol
- and 16 more
- 1 Claude 3.7 Sonnet 51.5%
- 2 Claude Opus 4 51.5%
- 3 Claude Sonnet 4 51.5%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude 3.7 Sonnet | 51.5% | Feb 2025 | Model card | |
| 2 | Claude Opus 4 | 51.5% | May 2025 | Model card | |
| 3 | Claude Sonnet 4 | 51.5% | May 2025 | Model card |
Number one over time
Lab claims count from the day the card came out, independent runs from the model’s release.
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 22 May 2025 | Claude Sonnet 4 system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than experts (7.2.4.5) | Bio and chem risk |
| 22 May 2025 | Claude Opus 4 system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than experts (7.2.4.5) | Bio and chem risk |
| 24 Feb 2025 | Claude 3.7 Sonnet system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than domain experts (7.1.4, Figure 17) | Bio and chem risk |
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