Benchmark Almanac

BioSecBench-Function

Claude Opus 5.5 73.6% leads since Sep 2026 Only in system cards

Agents recover biological function from experimental data. Scored by verifiable checks. One of three LatchBio BioSecBench evaluations.

Repo is Apache 2.0 with a public subset. Scored on benchmarks.bio V1 as a capability benchmark. Paper link pending.

Made by LatchBio Released Sep 2026 Genomics and life sciences Public tasks plus a private test set Last in a system card Sep 2026 Last model added Oct 2026 Scores refreshed 2 Nov 2026
Level
Expert Specialists with years of training, often over hours of work
Scored
Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
Answers
Agent task Many steps in a terminal, browser, desktop, app, game or robot.
latchbio/biosecbench-function 2 stars benchmarks.bio
27
Models scored on its own leaderboard
1
System card reports it, from 1 lab

Claude Opus 5.5 leads with 73.6%

Best score per model from the benchmark's own leaderboard, read on 2 Nov 2026. Where a model ran with several settings or harnesses, we keep its best.

27 models. Scroll sideways for the rest.

  1. 73.6 Claude Opus 5.5
  2. 53.5 Claude Sonnet 5.5
  3. 49.0 Claude Fable 5.1
  4. 48.6 GPT-6 Astra
  5. 46.0 GPT-6.1 Sol
  6. 44.8 Claude Opus 5
  7. 44.4 Gemini 4 Argon
  8. 44.0 Grok 4.6
  9. 43.3 Grok 4.7
  10. 43.1 Claude Opus 4.8
  11. 40.8 DeepSeek V4.1 Flash
  12. 39.3 GPT-6 Sol
  13. 39.0 GPT-6.1 Terra
  14. 36.0 Gemini 3.8 Flash
  15. 35.5 GPT-5.6 Sol
  16. 33.8 Claude Sonnet 5
  17. 33.7 Gemini 3.7 Flash
  18. 32.7 Kimi K3
  19. 31.8 GLM-5.3
  20. 30.8 Claude Opus 4.7
  21. 28.8 Mistral Large 4
  22. 28.3 GPT-5.5
  23. 27.6 GPT-5.6 Luna
  24. 27.3 Claude Sonnet 4.6
  25. 27.3 GPT-6 Luna
  26. 21.6 Nemotron 3 Ultra
  27. 13.8 Nemotron 3.5 Lightning 30B-A3B
  1. 1 Claude Opus 5.5 73.6%
  2. 2 Claude Sonnet 5.5 53.5%
  3. 3 Claude Fable 5.1 LSVP 49%
  4. 4 GPT-6 Astra 48.6%
  5. 5 GPT-6.1 Sol 46%
  6. 6 Claude Opus 5 44.8%
  7. 7 Gemini 4 Argon 44.4%
  8. 8 Grok 4.6 44%
  9. 9 Grok 4.7 43.3%
  10. 10 Claude Opus 4.8 43.1%
  11. 11 DeepSeek V4.1 Flash 40.8%
  12. 12 GPT-6 Sol 39.3%
  13. 13 GPT-6.1 Terra 39%
  14. 14 Gemini 3.8 Flash 36%
  15. 15 GPT-5.6 Sol 35.5%
  16. 16 Claude Sonnet 5 33.8%
  17. 17 Gemini 3.7 Flash 33.7%
  18. 18 Kimi K3 32.7%
  19. 19 GLM-5.3 31.8%
  20. 20 Claude Opus 4.7 30.8%
  21. 21 Mistral Large 4 28.8%
  22. 22 GPT-5.5 28.3%
  23. 23 GPT-5.6 Luna 27.6%
  24. 24 Claude Sonnet 4.6 27.3%
  25. 25 GPT-6 Luna 27.3%
  26. 26 Nemotron 3 Ultra 21.6%
  27. 27 Nemotron 3.5 Lightning 30B-A3B 13.8%
#ModelScoreSettingDateSource
1 Claude Opus 5.5 73.6% Pi Sep 2026 Official leaderboard
2 Claude Sonnet 5.5 53.5% Claude Code Sep 2026 Official leaderboard
3 Claude Fable 5.1 49% LSVP, Pi Sep 2026 Official leaderboard
4 GPT-6 Astra 48.6% Pi Sep 2026 Official leaderboard
5 GPT-6.1 Sol 46% Pi Sep 2026 Official leaderboard
6 Claude Opus 5 44.8% Claude Code Jul 2026 Official leaderboard
7 Gemini 4 Argon 44.4% Pi Sep 2026 Official leaderboard
8 Grok 4.6 44% Pi Aug 2026 Official leaderboard
9 Grok 4.7 43.3% Pi Sep 2026 Official leaderboard
10 Claude Opus 4.8 43.1% Pi May 2026 Official leaderboard
11 DeepSeek V4.1 Flash 40.8% Pi Sep 2026 Official leaderboard
12 GPT-6 Sol 39.3% Pi Sep 2026 Official leaderboard
13 GPT-6.1 Terra 39% Pi Oct 2026 Official leaderboard
14 Gemini 3.8 Flash 36% Pi Sep 2026 Official leaderboard
15 GPT-5.6 Sol 35.5% Codex Jul 2026 Official leaderboard
16 Claude Sonnet 5 33.8% Claude Code Jun 2026 Official leaderboard
17 Gemini 3.7 Flash 33.7% Pi Aug 2026 Official leaderboard
18 Kimi K3 32.7% Pi Jul 2026 Official leaderboard
19 GLM-5.3 31.8% Pi Aug 2026 Official leaderboard
20 Claude Opus 4.7 30.8% Pi Apr 2026 Official leaderboard
21 Mistral Large 4 28.8% Pi Oct 2026 Official leaderboard
22 GPT-5.5 28.3% Pi Apr 2026 Official leaderboard
23 GPT-5.6 Luna 27.6% Pi Jul 2026 Official leaderboard
24 Claude Sonnet 4.6 27.3% Claude Code Feb 2026 Official leaderboard
25 GPT-6 Luna 27.3% Pi Sep 2026 Official leaderboard
26 Nemotron 3 Ultra 21.6% Pi Jun 2026 Official leaderboard
27 Nemotron 3.5 Lightning 30B-A3B 13.8% Pi Aug 2026 Official leaderboard

Labs report scores for 1 model in their cards. We plot every source in the charts below.

2 models have held number one since its release in Sep 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic
Own leaderboard 2 leaders
Claude Opus 5.5 73.6%

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Fable 5.1 Claude Opus 5 Claude Opus 4.7 0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Fable 5.1

Labs report it only in system cards

We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.

One system card reports it

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
21 Sep 2026 Grok 4.7 model card 43.3 BioSecBench Function, endpoint pass rate, xhigh, Grok Build harness (7.1 table) Bio and chem risk

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