Biochemistry knowledge improvement
Models answer biochemistry tasks on structures, mutation thermodynamics, reaction products, arrow pushing and DNA phylogeny. Scored as reward@4.
OpenAI Preparedness evaluation. A 30 point jump over the previous model triggers further investigation.
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Short answer A number, word or short string matched to a key.
GPT-5.5 Pro leads with 39.3%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 GPT-5.5 Pro 39.3%
- 2 GPT-5.5 32.3%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-5.5 Pro | 39.3% | Apr 2026 | Model card | |
| 2 | GPT-5.5 | 32.3% | Apr 2026 | Model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
2 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 23 Apr 2026 | GPT-5.5 system card | 32.3 | Biochemistry knowledge improvement over GPT-5.4-thinking, reward@4 (Table 11) | Bio and chem risk |
| 23 Apr 2026 | GPT-5.5 Pro system card | 39.3 | Biochemistry knowledge improvement over GPT-5.4-thinking, reward@4, GPT-5.5 Pro (Table 11) | Bio and chem risk |
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