ProteinGym
Deep mutational scanning benchmarks. The model ranks mutations by predicted effect on protein function. Anthropic reports a hard subset.
The repo has releases PG_v1.0 to PG_v1.3 (April 2025) that add assays, so check which version a score used. Anthropic system cards report a ProteinGym Hard subset.
- Level
- Research frontier Researchers, on open problems or tasks that take days
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Short answer A number, word or short string matched to a key.
Claude Opus 5 leads with 47.7% among models released by Jul 2026
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in Jul 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- GPT-6 Astra
- Claude Opus 5.5
- GPT-6.1 Terra
- GPT-6.1 Sol
- and 14 more
- 1 Claude Opus 5 47.7%
- 2 Claude Opus 4.8 39.6%
- 3 Claude Sonnet 5 37%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 5 | 47.7% | Jul 2026 | Model card | |
| 2 | Claude Opus 4.8 | 39.6% | May 2026 | Model card | |
| 3 | Claude Sonnet 5 | 37% | Jun 2026 | Model card |
2 models have held number one since its release in Dec 2023
Lab claims count from the day the card came out, independent runs from the model’s release.
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 24 Jul 2026 | Claude Opus 5 system card | 47.7 | ProteinGym Hard, rank correlation with lab measurements reported as a percentage (8.17.3) | Capabilities |
| 30 Jun 2026 | Claude Sonnet 5 system card | 37 | ProteinGym Hard, score 0.37 (8.14.4, Figure 8.14.6.A) | Capabilities |
| 28 May 2026 | Claude Opus 4.8 system card | 39.6 | ProteinGym Hard, rank correlation with lab measurements reported as 39.6% (8.16.5) | Capabilities |
More in Science and reasoning
- GPQA Diamond In use 198 graduate-level 'Google-proof' multiple-choice questions in biology, chemistry and physics.
Gemini 4 Argon 96.4% - Terminal-Bench-Science In use 70 scientific research-workflow tasks across five science areas, run in Harbor containers. Hidden tests give the resolution rate. GPT-6 Astra 68.1%
- FrontierScience In use Models solve physics, chemistry, and biology problems in an Olympiad track graded by short answer and a Research track graded by 10-point rubrics.
Intern-S2-397B 87% - BioMysteryBench In use Bioinformatics problems on anonymized real datasets that require real analysis with tools. Rubric-graded, with human-solvable and human-difficult splits. Claude Opus 5 90.1%
- HiPhO In use Models solve theory problems from 2024 and 2025 physics olympiad exams, some with diagrams. Official marking schemes grade answers and steps, mapped to medal levels. Gemini 3 Pro 78.3%
- LABBench2 In use 11 biology research sub-tasks (literature, figures, tables, patents, trials and more) with tool access. Macro-averaged accuracy. GPT-5.2 60.9%