Protein Design (Anthropic)
Models generate novel protein sequences under design constraints and rank protein design libraries for experimental testing.
Reported as two tasks, Sequence Generation and Library Ranking, with no overall score.
- Level
- Expert Specialists with years of training, often over hours of work
- Scored
- Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
- Answers
- Open-ended Free-form text, documents, designs or media judged as a whole.
Claude Opus 5 leads with 42.5%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 Claude Opus 5 42.5%
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 5 | 42.5% | Jul 2026 | Model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Labs report it only in system cards
We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.
4 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| 7 Oct 2026 | Claude Haiku 5.5 system card | Protein design, Sequence Generation 33.1 and Library Ranking 45.3, no overall (8.13.4) | Capabilities | |
| 28 Sep 2026 | Claude Sonnet 5.5 system card | Protein Design, Sequence Generation 51.0% and Library Ranking 54.8%, no overall (8.17.5, Figure 8.17.A) | Capabilities | |
| 22 Sep 2026 | Claude Opus 5.5 system card | Protein design, Sequence Generation 60.2% and Library Ranking 56.0%, no overall (8.17.5) | Capabilities | |
| 24 Jul 2026 | Claude Opus 5 system card | 42.5 | Protein Design, single score for constraint satisfaction, folding confidence and novelty, no tools (8.17.4) | Capabilities |
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