Benchmark Almanac

Morphology-to-molecule matching (Anthropic)

Claude Opus 5.5 34% leads since Sep 2026 Only in system cards

Models match four sets of multi-channel liver cell images to the four shuffled molecule and dose treatments that produced them.

Built with Axiom Bio from its in-vitro liver assay data.

Made by Anthropic (with Axiom Bio) Released Sep 2026 Research science Tasks kept private Last in a system card Oct 2026 Last model added Oct 2026
Level
Expert Specialists with years of training, often over hours of work
Scored
Checked automatically A program checks the result against an answer key, unit tests or the expected final state.
Answers
Short answer A number, word or short string matched to a key.
3
Models scored in lab cards
3
System cards report it, from 1 lab

Claude Opus 5.5 leads with 34%

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

  1. 34.0 Claude Opus 5.5
  2. 25.4 Claude Haiku 5.5
  3. 25.0 Claude Sonnet 5.5
  1. 1 Claude Opus 5.5 34%
  2. 2 Claude Haiku 5.5 25.4%
  3. 3 Claude Sonnet 5.5 25%
#ModelScoreSettingDateSource
1 Claude Opus 5.5 34% Sep 2026 Model card
2 Claude Haiku 5.5 25.4% Oct 2026 Model card
3 Claude Sonnet 5.5 25% Sep 2026 Model card

Number one over time

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic
Lab claims 1 leader
Claude Opus 5.5 34%

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card
0% 20% 40% 60% 80% 100% Near the ceiling (85%) Claude Opus 5.5 0% 20% 40% 60% 80% 100% Near the ceiling (85%) Claude Opus 5.5

Labs report it only in system cards

We read the headline results of 479 launch posts from 51 labs, and none of them list this benchmark. Some system cards do, below.

3 system cards report it, from 1 lab

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
7 Oct 2026 Claude Haiku 5.5 system card 25.4 Morphology-to-molecule matching, max effort (8.13.2) Capabilities
28 Sep 2026 Claude Sonnet 5.5 system card 25 Morphology-to-molecule matching (8.17.3, Figure 8.17.A) Capabilities
22 Sep 2026 Claude Opus 5.5 system card 34 Morphology-to-molecule matching (Axiom Bio liver assay), max effort (8.17.3) Capabilities

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